Molecular genetics of nucleoside transporters in Leishmania and African trypanosomes

Authors
Citation
Sm. Landfear, Molecular genetics of nucleoside transporters in Leishmania and African trypanosomes, BIOCH PHARM, 62(2), 2001, pp. 149-155
Citations number
42
Language
INGLESE
art.tipo
Editorial Material
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOCHEMICAL PHARMACOLOGY
ISSN journal
0006-2952 → ACNP
Volume
62
Issue
2
Year of publication
2001
Pages
149 - 155
Database
ISI
SICI code
0006-2952(20010715)62:2<149:MGONTI>2.0.ZU;2-G
Abstract
Nucleoside transporters play central roles in the biochemistry of parasitic protozoa such as Leishmania and African trypanosomes, because these parasi tes cannot synthesize purines de novo and are absolutely reliant upon purin e salvage from their hosts. Furthermore, nucleoside transporters are import ant to the pharmacology of these significant human pathogens, because they mediate the uptake of purine analogs, as well as some non-purine drugs, tha t are selectively cytotoxic to the parasites. Recent advances in molecular biology and genomics have allowed the cloning and functional expression of several nucleoside transporter genes from Leishmania donovani and Trypanoso ma brucei, providing molecular reagents for a detailed functional examinati on of these permeases and their role in the delivery of nutrients and drugs to the parasites. Furthermore, the molecular basis of drug-resistant mutan ts that are deficient in nucleoside transport functions can now be fathomed . (C) 2001 Elsevier Science Inc. All rights reserved.