Effects of prenatal rubratoxin-B exposure on behaviors of mouse offspring

Citation
T. Kihara et al., Effects of prenatal rubratoxin-B exposure on behaviors of mouse offspring, TOXICOL SCI, 61(2), 2001, pp. 368-373
Citations number
41
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
TOXICOLOGICAL SCIENCES
ISSN journal
1096-6080 → ACNP
Volume
61
Issue
2
Year of publication
2001
Pages
368 - 373
Database
ISI
SICI code
1096-6080(200106)61:2<368:EOPREO>2.0.ZU;2-E
Abstract
The effects of prenatal rubratoxin-B (RB) exposure on 8 behavioral paramete rs in Jc1:ICR mice were assessed. Pregnant mice were injected intraperitone ally with 0.1 or 0.2 mg/kg/day of RE dissolved in propylene glycol water so lution on days 7-9 (Group A) or 10-12 (Group E) of gestation. Controls rece ived the vehicle similarly on days 7-12 of gestation. Before weaning, the o ffspring of both sexes were examined to test their the surface righting ref lex (5 days of age), cliff avoidance response (6 days), negative geotaxis r esponse (7 days), and swimming development (8, 10, and 12 days). After wean ing, male animals were examined using the rotarod test (6 weeks of age), th e open-field test (7 weeks), the shuttle-box-avoidance-learning test (9 wee ks), and the water E-maze test (10 weeks). The preweanling offspring in the 0.2 mg/kg-B group showed significantly lower success rates and longer resp onse times than controls in the cliff-avoidance response. In swimming devel opment, the offspring in the 0.2 mg/kg B group had significantly lower scor es than controls for swimming angle at 10 and 12 days of age. The avoidance learning of the mice in all RE-exposed A and B groups was significantly po orer than that of controls. These results indicate that prenatal exposure t o RE produced a delay of early response development and impaired learning a bility in the offspring of mice exposed to RE during middle pregnancy.