In silico mapping of complex disease-related traits in mice

Citation
A. Grupe et al., In silico mapping of complex disease-related traits in mice, SCIENCE, 292(5523), 2001, pp. 1915-1918
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Multidisciplinary,Multidisciplinary,Multidisciplinary
Journal title
SCIENCE
ISSN journal
0036-8075 → ACNP
Volume
292
Issue
5523
Year of publication
2001
Pages
1915 - 1918
Database
ISI
SICI code
0036-8075(20010608)292:5523<1915:ISMOCD>2.0.ZU;2-3
Abstract
Experimental murine genetic models of complex human disease show great pote ntial for understanding human disease pathogenesis. To reduce the time requ ired for analysis of such models from many months down to milliseconds, a c omputational method for predicting chromosomal regions regulating phenotypi c traits and a murine database of single nucleotide polymorphisms were deve loped. After entry of phenotypic information obtained from inbred mouse str ains, the phenotypic and genotypic information is analyzed in silico to pre dict the chromosomal regions regulating the phenotypic trait.