Obsessive-compulsive disorder in hospitalized patients with chronic schizophrenia

Citation
M. Poyurovsky et al., Obsessive-compulsive disorder in hospitalized patients with chronic schizophrenia, PSYCHIAT R, 102(1), 2001, pp. 49-57
Citations number
35
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Psychiatry,"Neurosciences & Behavoir
Journal title
PSYCHIATRY RESEARCH
ISSN journal
0165-1781 → ACNP
Volume
102
Issue
1
Year of publication
2001
Pages
49 - 57
Database
ISI
SICI code
0165-1781(20010510)102:1<49:ODIHPW>2.0.ZU;2-S
Abstract
Obsessive-compulsive (OC) symptoms have been observed in a substantial prop ortion of schizophrenic patients. In this study, we assessed the rate of oc currence of OC symptoms and the interrelationship between OC and schizophre nic symptoms in 68 hospitalized chronic schizophrenic patients. The patient s were interviewed with the Structured Clinical Interview fur Axis-I DSM-IV Disorders - Patient Edition (SCID-P) and the appropriate rating scales inc luding the Scale for the Assessment of Positive Symptoms, the Scale for the Assessment of Negative Symptoms, the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), the Barnes Akathisia Scale, the Abnormal Involuntary Movement Sc ale, and the Social Behaviour Schedule (SBS), Sixteen patients (23.5%) met the DSM-IV criteria for OCD. A comparison of schizophrenic patients with an d without OCD showed that the schizo-obsessive patients were significantly (1.7-fold) more impaired in basic social functioning, as reflected by the S BS score. No significant between-group differences for any of the other cli nical variables were found. There was no significant correlation between OC and schizophrenic symptoms within the schizo-obsessive subgroup. The mean Y-BOCS score for the patients with both schizophrenia and OCD was within th e typical range (22.8 +/- 1.7) observed in OCD without psychosis. The findi ngs provide further evidence for the importance of the OC dimension in schi zophrenia and may have important implications for the application of effect ive treatment approaches in this difficult-to-treat subgroup of schizophren ic patients. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.