An fMRI study of anticipation and learning of smooth pursuit eye movementsin humans

Citation
A. Schmid et al., An fMRI study of anticipation and learning of smooth pursuit eye movementsin humans, NEUROREPORT, 12(7), 2001, pp. 1409-1414
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
0959-4965 → ACNP
Volume
12
Issue
7
Year of publication
2001
Pages
1409 - 1414
Database
ISI
SICI code
0959-4965(20010525)12:7<1409:AFSOAA>2.0.ZU;2-C
Abstract
We studied the neural substrate of anticipation and learning of smooth purs uit eye movements in humans using fMRI. Both predictable and non-predictabl e eye movements, compared to baseline, activated a common network previousl y associated with oculomotor function. The temporal dynamics of activity in a subset of these areas suggested a strong correlation with type of condit ion. Specifically, differential decreases in activity were seen in dorsolat eral prefrontal cortex and the intraparietal sulcus during the predictable condition. During the non-predictable condition the same areas exhibited ev idence of high levels of activity that further increased throughout the con dition. In contrast, differential increases associated:with the predictable condition were seen in anterior cingulate and preSMA cortex regions. These changes in activity mirror the time course of the short-term learning of e ye movements seen behaviourally, and;are congruent with learning-related ch anges that have been reported for other motor paradigms. NeuroReport 12:140 9-1414 (C) 2001 Lippincott Williams & Wilkins.