Microglial activation induced by beta-amyloid (A beta) is an important cell
ular response in the pathogenesis of Alzheimer's disease (AD). In this stud
y, we show that reactive oxygen species (ROS) play a role as signaling mole
cules for the activation of NF-kappaB and induction of IL-1 beta mRNA expre
ssion in A beta (25-35)-treated murine microglia BV-2 cells. ROS scavengers
such as catalase and superoxide dismutase (SOD) mimetics obviously reduced
activation of NF-kappaB and the elevated level of IL-1 beta transcripts in
duced by A beta (25-35). In addition, the A beta (25-35)-induced NF-kappaB
activation and IL-1 beta expression were suppressed by blockers of the ROS
generating enzymes such as NADPH oxidase, cyclooxygenase, and lipoxygenase.
These data suggest that ROS mediate A beta -induced microglial activation.
NeuroReport 12:1449-1452 (C) 2001 Lippincott Williams & Wilkins.