EAAT1 and EAAT2 immunoreactivity in transgenic mice with a G93A mutant SODI gene

Citation
S. Sasaki et al., EAAT1 and EAAT2 immunoreactivity in transgenic mice with a G93A mutant SODI gene, NEUROREPORT, 12(7), 2001, pp. 1359-1362
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
0959-4965 → ACNP
Volume
12
Issue
7
Year of publication
2001
Pages
1359 - 1362
Database
ISI
SICI code
0959-4965(20010525)12:7<1359:EAEIIT>2.0.ZU;2-D
Abstract
Immunocytochemical and quantitative analyses were used to correlate the loc alisation of excitatory amino acid transporter proteins EAAT1, EAAT2 with t ime in spinal motoneurones of presymptomatic and symptomatic mice with the G93A mutant SOD1 gene. Specimens from age-matched non-transgenic wildtype m ice served as controls. EAAT1 and EAAT2 immunoreactivity was well-preserved in the gray matter in both controls and transgenic mice at all ages, and t here-was no difference in the expression-of EAAT1 and EAAT2 immunoreactivit y between controls and transgenic mice. These findings suggest that EAAT1. and EAAT2 may not play a pivotal role in the degeneration of motoneurons in this animal model. NeuroReport 12:1359-1362. (C) 2001 Lippincott Williams & Wilkins.