Anti-oxidized low-density-lipoprotein (OxLDL) antibodies in systemic lupuserythematosus with and without antiphospholipid syndrome

Citation
G. Hayem et al., Anti-oxidized low-density-lipoprotein (OxLDL) antibodies in systemic lupuserythematosus with and without antiphospholipid syndrome, LUPUS, 10(5), 2001, pp. 346-351
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Rheumatology
Journal title
LUPUS
ISSN journal
0961-2033 → ACNP
Volume
10
Issue
5
Year of publication
2001
Pages
346 - 351
Database
ISI
SICI code
0961-2033(2001)10:5<346:AL(AIS>2.0.ZU;2-W
Abstract
The aim of this study was to examine potential links between antiOxLDL anti bodies and the clinical and biological features of secondary antiphospholip id syndrome (II APLS) associated with systemic lupus erythematosus (SLE). A cohort study was done of 98 SLE patients followed-up for 1 y, including 1 8 with definite II APLS and 13 patients with definite primary APLS (I APLS) . IgG anticardiolipin, IgG anti beta2 GPI, lupus anticoagulant, VDRL and Ig G antiOxLDL were measured in all 98 study subjects. High antiOxLDL titers were found in seven (39%) of the 18 patients with II APLS vs 10 ( 12.5%) of the 80 patients without APLS (P < 0.01; OR = 4.45; 9 50% CI = 1.4-14.1) and none of the 13 patients with I APLS (P < 0.02). The mean antiOxLDL titer was not significantly higher in the SLE patients with than without II APLS (P > 0.05). A high antiOxLDL titer was correlated with deep venous thrombosis (P < 0.01; OR= 5.77; 95% CI = 0.54-61) but not with arterial thrombosis (P > 0.05 OR = 1; 95% CI = 0.29-3.09), thrombocytopeni a, central nervous system involvement, livedo reticularis, or a positive Co ombs test, The antiOxLDL antibody titer was correlated with the IgG anticar diolipin antibody titer (r = 0.235; P = 0.02) and with the IgG anti-beta2 G PI antibody titer (r = 0.224, P = 0.026). AntiOxLDL elevation was found in 17% of SLE patients and was significantly associated with II Introduction APLS and venous thrombosis, We found no evi dence suggesting that antiOxLDL may be associated with atherosclerosis.