Effects of one-legged endurance training on femoral arterial and venous size in healthy humans

Citation
M. Miyachi et al., Effects of one-legged endurance training on femoral arterial and venous size in healthy humans, J APP PHYSL, 90(6), 2001, pp. 2439-2444
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Physiology
Journal title
JOURNAL OF APPLIED PHYSIOLOGY
ISSN journal
8750-7587 → ACNP
Volume
90
Issue
6
Year of publication
2001
Pages
2439 - 2444
Database
ISI
SICI code
8750-7587(200106)90:6<2439:EOOETO>2.0.ZU;2-F
Abstract
The cross-sectional area (CSA) of large-conductance arteries increases in r esponse to endurance training in humans. To determine whether training-indu ced changes in arterial structure are systemic in nature or, rather, are co nfined to the arteries supplying exercising muscles, we studied 10 young me n who performed one-legged cycle training [80% of one-legged peak O-2 uptak e ((V) over dot O-2peak), 40 min/day, 4 days/wk] for 6 wk and detraining fo r another 6 wk. There were no significant differences in baseline one-legge d (V) over dot O-2peak and CSA of the common femoral artery and vein (via B -mode ultrasound) between experimental and control legs. In the experimenta l leg, one-legged (V) over dot O-2peak increased 16% [from 3.0 +/- 0.1 to 3 .4 +/- 0.1 (SE) l/min], arterial CSA increased 16% (from 84 +/- 3 to 976+/- 5 mm(2)), and venous CSA increased 46% (from 56 +/- 5 to 82 +/- 5 mm(2)) a fter endurance training. These changes returned to baseline during detraini ng. There were no changes in one-legged (V) over dot O-2peak and arterial C SA in the control leg, whereas femoral venous CSA in the control leg signif icantly increased 24% (from 54 +/- 5 to 67 +/- 4 mm(2)) during training. Ch anges in femoral arterial and venous CSA in the experimental leg were posit ively and significantly related to corresponding changes in one-legged (V) over dot O-2peak (r = 0.86 and 0.76, respectively), whereas there were no s uch relations in the control leg (r = 0.10 and 0.17). When stepwise regress ion analysis was performed, a primary determinant of change in (V) over dot O-2peak was change in femoral arterial CSA, explaining similar to 70% of t he variability. These results support the hypothesis that the regional incr ease in blood flow, rather than systemic factors, is associated with the tr aining-induced arterial expansion. Femoral arterial expansion may contribut e, at least in part, to improvement in efficiency of blood transport from t he heart to exercising muscles and may facilitate achievement of aerobic wo rk capacity.