Nucleotide sequence analysis of the binding site on the inositol 1,4,5-trisphosphate type-1 receptor in bipolar disorder - a negative study

Citation
K. Fujimaki et al., Nucleotide sequence analysis of the binding site on the inositol 1,4,5-trisphosphate type-1 receptor in bipolar disorder - a negative study, J AFFECT D, 65(2), 2001, pp. 139-143
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Psychiatry,"Neurosciences & Behavoir
Journal title
JOURNAL OF AFFECTIVE DISORDERS
ISSN journal
0165-0327 → ACNP
Volume
65
Issue
2
Year of publication
2001
Pages
139 - 143
Database
ISI
SICI code
0165-0327(200107)65:2<139:NSAOTB>2.0.ZU;2-0
Abstract
Pharmacological studies of bipolar disorder suggest that dysfunction of cal cium mobilization via phosphatidylinositol-mediated transduction may be inv olved in its pathogenesis. The present study tests the hypothesis that dysf unction of calcium mobilization in bipolar disorder is due to the mutation of the nucleotide sequence in the FKBP12 binding site on the inositol 1,4,5 -trisphosphate type-1 receptor (IP(3)R1). Nucleotide sequence analysis of t he FKBP12 binding site on IP(3)R1 was performed using reverse transcription -polymerase chain reaction and DNA sequencing. The nucleotide sequence in t his region was preserved in all subjects. This finding suggests that IP(3)R 1 dysfunction through the FKBP12 binding site is not involved in the pathog enesis of bipolar disorder. (C) 2001 Elsevier Science B.V. All rights reser ved.