K. Fujimaki et al., Nucleotide sequence analysis of the binding site on the inositol 1,4,5-trisphosphate type-1 receptor in bipolar disorder - a negative study, J AFFECT D, 65(2), 2001, pp. 139-143
Pharmacological studies of bipolar disorder suggest that dysfunction of cal
cium mobilization via phosphatidylinositol-mediated transduction may be inv
olved in its pathogenesis. The present study tests the hypothesis that dysf
unction of calcium mobilization in bipolar disorder is due to the mutation
of the nucleotide sequence in the FKBP12 binding site on the inositol 1,4,5
-trisphosphate type-1 receptor (IP(3)R1). Nucleotide sequence analysis of t
he FKBP12 binding site on IP(3)R1 was performed using reverse transcription
-polymerase chain reaction and DNA sequencing. The nucleotide sequence in t
his region was preserved in all subjects. This finding suggests that IP(3)R
1 dysfunction through the FKBP12 binding site is not involved in the pathog
enesis of bipolar disorder. (C) 2001 Elsevier Science B.V. All rights reser
ved.