Genomic imbalances in human lung adenocarcinomas and squamous cell carcinomas

Citation
Jm. Pei et al., Genomic imbalances in human lung adenocarcinomas and squamous cell carcinomas, GENE CHROM, 31(3), 2001, pp. 282-287
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
GENES CHROMOSOMES & CANCER
ISSN journal
1045-2257 → ACNP
Volume
31
Issue
3
Year of publication
2001
Pages
282 - 287
Database
ISI
SICI code
1045-2257(200107)31:3<282:GIIHLA>2.0.ZU;2-H
Abstract
Comparative genomic hybridization analysis was performed on 67 non-small-ce ll lung cancers (NSCLCs), including 32 squamous cell carcinomas (SCCs) and 35 adenocarcinomas (ACs), to identify differences in the patterns of genomi c imbalance between these two histologic subtypes. Among the entire tumor s et. the chromosome arms most often overrepresented were 1q, 3q, 5p, and 8q, each detected in 50-55% of cases. The most frequently underrepresented arm s were 9q, 3p, 8p, and 17p. The number of imbalances was similar in SCCs an d ACs (median number/case: 12 and 11, respectively). Moreover, many imbalan ces, such as gains of 1q, 5p, and 8q, occurred at a high frequency in both histologic subgroups. Several statistically significant differences, howeve r, were found. The mon prominent difference was gain of 3q24-qter, seen in 81% of SCCs compared with 31% of ACs (P < 0.0001), with amplification at 3q 25-26 being detected in eight of 32 (25%) SCCs but in only two of 35 (6%) A Cs. Gain of 20p13 and loss of 4q also were seen at a significantly higher r ate in SCCs than in ACs, whereas overrepresentation of 6p was more common i n ACs. Gains of 7q and 8q each were associated with higher-stage tumors and either positive nodal involvement or higher tumor grade. These data sugges t that genes located in several chromosomal regions, particularly 3q25-26, may be associated with phenotypic properties that differentiate lung SCCs f rom ACs. Furthermore, certain imbalances, prominent among them gains of 7q and 8q, may be indicative of tumor aggressiveness in NSCLCs. (C) 2001 Wille y-Liss, Inc.