High birth weight and other risk factors for Wilms tumour: results of a population-based case-central study

Citation
J. Schuz et al., High birth weight and other risk factors for Wilms tumour: results of a population-based case-central study, EUR J PED, 160(6), 2001, pp. 333-338
Citations number
41
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pediatrics,"Medical Research General Topics
Journal title
EUROPEAN JOURNAL OF PEDIATRICS
ISSN journal
0340-6199 → ACNP
Volume
160
Issue
6
Year of publication
2001
Pages
333 - 338
Database
ISI
SICI code
0340-6199(200106)160:6<333:HBWAOR>2.0.ZU;2-X
Abstract
Wilms tumour, or nephroblastoma, is one of the childhood cancers included i n two recent population-based case-control studies in West Germany. Altoget her, 177 children under the age of 10 years with Wilms tumour diagnosed bet ween 1988 and 1994 and 2006 control children sampled from population regist ration files participated. Information on potential risk factors was obtain ed from the parents using a questionnaire and by subsequent telephone inter view. We found an association with a high birth weight >4000 g (odds ratio 1.58; 95% confidence interval 1.01-2.48), which was somewhat stronger for c hildren aged 2 years or older. Findings for young maternal age at birth and certain parental occupationally related exposures were not reported by pre vious studies and thus may be chance findings. As opposed to previous studi es, we failed to confirm associations with high parental age at birth, mate rnal coffee and tea consumption during pregnancy, and exposure to pesticide s. Conclusion Based on this large population-based case-control study, high bi rth weight may play a role in the aetiology of Wilms tumour, but many risk factors previously suggested are of less importance.