Steroidal glycosides from the bulbs of Camassia leichtlinii and their cytotoxic activities

Citation
M. Kuroda et al., Steroidal glycosides from the bulbs of Camassia leichtlinii and their cytotoxic activities, CHEM PHARM, 49(6), 2001, pp. 726-731
Citations number
12
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
0009-2363 → ACNP
Volume
49
Issue
6
Year of publication
2001
Pages
726 - 731
Database
ISI
SICI code
0009-2363(200106)49:6<726:SGFTBO>2.0.ZU;2-B
Abstract
Phytochemical analysis of the bulbs of Camassia leichtlinii (Liliaceae) res ulted in the isolation of six new spirostanol saponins, a new furostanol sa ponin, a cholestane glucoside, and four known steroidal saponins. The struc tures of the new saponins were determined by detailed analysis of their spe ctral data, including two-dimensional NMR spectroscopy, and by the results of hydrolytic cleavage. Cytotoxic activities of the isolated compounds agai nst human oral squamous cell carcinoma (HSC-2) cells and normal human gingi val fibroblasts (HGF) are also reported.