4G/5G polymorphism of the plasminogen activator inhibitor-1 gene and insertion/deletion polymorphism of the tissue-type plasminogen activator gene inatherothrombotic stroke

Citation
Co. Bang et al., 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene and insertion/deletion polymorphism of the tissue-type plasminogen activator gene inatherothrombotic stroke, CEREB DIS, 11(4), 2001, pp. 294-299
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
CEREBROVASCULAR DISEASES
ISSN journal
1015-9770 → ACNP
Volume
11
Issue
4
Year of publication
2001
Pages
294 - 299
Database
ISI
SICI code
1015-9770(2001)11:4<294:4POTPA>2.0.ZU;2-Z
Abstract
Background and Purpose: Decreased fibrinolytic capacity due to increased pl asminogen activator inhibitor-1 (PAI-1) activity and decreased tissue-type plasminogen activator (t-PA) activity has been associated with hypertension or atherothrombotic disorders. The aims of this study were to observe asso ciations of the genetic polymorphism for PAI-1 and t-PA with hypertension a nd atherothrombotic stroke, and to elucidate whether impaired fibrinolytic activity in atherothrombotic stroke was related to atherothrombosis per se or to other risk factors such as hypertension. Methods: Patients with ather othrombotic stroke (n = 60), hypertension (n = 100), and control subjects ( n = 100) were enrolled. We genotyped all subjects for 4G/5G polymorphism in the promoter region of the PAI-1 gene and the Alu-repeat insertion/deletio n (I/D) polymorphism in intron h of the t-PA gene by polymerase chain react ion and endonuclease digestion. Results: The frequency of th e 4G/4G genoty pe of PAI-1 was significanlty higher in the atherothombotic stroke patients than the control subjects (41.7 versus 21%; p = 0.005), but not in the hyp ertensive subjects. There was a significant association between 4G/4G genot ype of PAI-1 and atherothrombotic stroke (adjusted odds ratio = 3.11, 95% c onfidence interval 1.18-8.15), adjusting for age, sex, total cholesterol, l ow-density lipoprotein, triglyceride, and body mass index. However, the num ber of the I/I genotype of t-PA in the atherothrombotic stroke or hypertens ive patients was virtually identical to the control subjects. Conclusion: O ur results suggest that the 4G/4G genotype of the PAI-1 gene is significant ly associated with an increased risk of atherothrombotic stroke. This findi ng also supports that impaired fibrinolytic activity in atherothrombotic st roke is related to atherothrombosis per se, but not to hypertension, one of the most important risk factors of atherothrombotic stroke. Copyright (C) 2001 S. Karger AG, Basel.