Regular consumption of green tea and the risk of breast cancer recurrence:follow-up study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC), Japan

Citation
M. Inoue et al., Regular consumption of green tea and the risk of breast cancer recurrence:follow-up study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC), Japan, CANCER LETT, 167(2), 2001, pp. 175-182
Citations number
34
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER LETTERS
ISSN journal
0304-3835 → ACNP
Volume
167
Issue
2
Year of publication
2001
Pages
175 - 182
Database
ISI
SICI code
0304-3835(20010626)167:2<175:RCOGTA>2.0.ZU;2-0
Abstract
Experimental studies suggest various features of anticancer activity of gre en tea including inhibitory effect of tumor invasion and metastasis. This s tudy was conducted to examine the association between regular green tea con sumption prior to diagnosis and subsequent risk of breast cancer recurrence . The Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC) was started in 1988, in which information on lifestyle has routin ely been collected from all first-visit outpatients by questionnaire. A tot al of 1160 new surgical cases of female invasive breast cancers with HERPAC C information diagnosed between June 1990 and August 1998 were followed up through December 1999, and the risk (hazard ratio: HR) of recurrence was as sessed with reference to daily green tea consumption using a Cox proportion al hazard model. During 5264 person-years of follow-up, 133 subjects (12%) were documented to suffer recurrence of breast cancer. A decreased HR for r ecurrence adjusted for stage was observed with consumption of three or more daily cups of green tea (HR = 0.69, 95% confidence interval (95%)=0.47-1.0 0). particularly in stage I, the HR was decreased statistically significant ly (HR = 0.43, 95%CI = 0.22-0.84). A similar tendency was observed for stag e II subjects, bur was not present among more advanced stages. Although car eful interpretation is needed, these results suggest the possibility that r egular green tea consumption may be preventive against recurrence of breast cancer in early stage cases. (C) 2001 Elsevier Science Ireland Ltd. All ri ghts reserved.