Response to influenza immunisation during treatment for cancer

Citation
Jc. Chisholm et al., Response to influenza immunisation during treatment for cancer, ARCH DIS CH, 84(6), 2001, pp. 496-500
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pediatrics,"Medical Research General Topics
Journal title
ARCHIVES OF DISEASE IN CHILDHOOD
ISSN journal
0003-9888 → ACNP
Volume
84
Issue
6
Year of publication
2001
Pages
496 - 500
Database
ISI
SICI code
0003-9888(200106)84:6<496:RTIIDT>2.0.ZU;2-G
Abstract
Aims - To assess the annual risk of influenza infection in children with ca ncer and the immunogenicity of a trivalent split virus influenza vaccine in these children. Methods -Eighty four children with cancer were tested for susceptibility to the circulating strains of influenza virus in autumn 1995 and 1996. Non-im munised children were reassessed the following spring for serological evide nce of natural infection. Forty two patients received two doses of influenz a vaccine. These children were receiving continuing chemotherapy for acute lymphoblastic leukaemia or were within six months of completing chemotherap y. Results - Among the 84 children tested for influenza virus susceptibility o nly 8% of patients were fully protected (antibody titres greater than or eq ual to 40) against all three of the prevalent influenza virus strains; 33% were susceptible to all three viruses. Evidence of acquired natural infecti on was seen in 30% of unimmunised patients. Among immunised susceptible pat ients, 66% made some protective response to the vaccine and 55% showed prot ective antibody titres to all three viral strains following vaccination. Ol der age was associated with increased response to the H1N1 and H3N2 vaccine components, but total white cell count or neutrophil count at immunisation , type of cancer, or length of time on treatment for acute lymphoblastic le ukaemia did not affect response. Conclusions - Most children with cancer studied were at risk of influenza i nfection. A significant response to immunisation was seen, supporting annua l influenza vaccination for children being treated for cancer.