Development of an enhanced anticaries efficacy dual component dentifrice containing sodium fluoride and dicalcium phosphate dihydrate

Rj. Sullivan et al., Development of an enhanced anticaries efficacy dual component dentifrice containing sodium fluoride and dicalcium phosphate dihydrate, AM J DENT, 14, 2001, pp. 3A-11A
Citations number
Categorie Soggetti
Dentistry/Oral Surgery & Medicine
Journal title
ISSN journal
0894-8275 → ACNP
Year of publication
3A - 11A
SICI code
A dual-chamber dentifrice, which contains sodium fluoride (NaF) in one comp onent and dicalcium phosphate dihydrate (dical) in the other, has been deve loped. The dentifrice is packaged in a dual-chamber tube and is formulated to deliver 1100 ppm F. A series of studies consisting of in vitro fluoride uptake, in vivo calcium labeling, intraoral remineralization-demineralizati on, and animal caries studies were performed to support the improved antica ries efficacy of this product in comparison to a sodium fluoride/silica den tifrice (NaF/silica). An in vitro fluoride uptake study comparing 1100 ppm F NaF/dical dentifrice to 1100 ppm F NaF/silica showed that NaF/dical deliv ered significantly more fluoride than NaF/silica, 3.72 +/- 0.36 mug/cm(2) v ersus 2.41 +/- 0.10 mug/cm(2). A 6-day in vivo brushing study with a Ca-44 labeled NaF/dical dentifrice showed that calcium from dical penetrated demi neralized enamel and was present in plaque up to 18 hrs since the last brus hing. An intra-oral remineralization-demineralization study was performed t o evaluate NaF/dical's ability to promote remineralization in comparison to three silica-based dentifrices containing 0, 250, and 1100 ppm F as NaF. T he percent mineral changes after treatment were +20.44 +/- 17.14 for NaF/di cal, +9.27 +/- 19.53 for 1100 ppm NaF/silica, -1.43 +/- 20.57 for 250 ppm N aF/silica, and -12.36 +/- 32.76 for 0 ppm F/silica. A statistical analysis showed that the dual-chamber NaF/dical dentifrice was significantly more ef fective than the 1100 ppm NaF/silica dentifrice at promoting remineralizati on. A rat caries study was performed to evaluate NaF/dical ability to preve nt caries in comparison to 1100 ppm F NaF/silica, 250 ppm F NaFisilica, sil ica, and dical dentifrices. The mean smooth surface caries scores were 1.6 +/- 2.8 for NaF/dical, 5.5 +/- 6.2 for 1100 ppm F NaF/silica, 10.6 +/- 6.2 for 250 ppm (N) over dot F/silica, 13.7 +/- 4.7 for 0 ppm F/silica, and 9.5 +/- 7.8 0 ppm F/dical. A statistical analysis showed that the the dual-cha mber NaF/dical dentifrice was superior to all other treatments tested in pr eventing caries in rats. The dical dentifrice was significantly superior to the silica dentifrice in preventing caries, which indicates that dical alo ne exhibits anticaries efficacy. In conclusion, individual and cumulative r esults from the fluoride uptake, intra-oral remineralization-demineralizati on, and rat caries studies from the dual chamber NaF/dical dentifrice suppo rt the improved anticaries efficacy of this product.