Correlation between biopsy and radical cystectomy in assessing grade and depth of invasion in bladder urothelial carcinoma

Bs. Chang et al., Correlation between biopsy and radical cystectomy in assessing grade and depth of invasion in bladder urothelial carcinoma, UROLOGY, 57(6), 2001, pp. 1063-1066
Citations number
Categorie Soggetti
Urology & Nephrology
Journal title
ISSN journal
0090-4295 → ACNP
Year of publication
1063 - 1066
SICI code
Objectives. To assess the degree of correlation between the pathologic char acteristics of the specimens obtained from biopsy and radical cystoprostate ctomy. The stage and grade of bladder urothelial (transitional cell) carcin oma are important predictors of prognosis. Methods. We retrospectively identified 169 cases of urothelial carcinoma fr om 222 radical cystectomies performed at University of Chicago Hospitals fr om 1992 to 1999. Results. For all the cases in this study, the histologic grade, using the 1 998 World Health Organization and International Society of Urological Patho logists (WHO/ISUP) classification, was identical when the biopsy specimen a nd radical cystectomy specimen were compared. However, when the same cases were assessed using the traditional three-grade system, the histologic grad e increased or decreased by one grade in 19 (11%) and 8 (5%) of 169 cases, respectively. Patients with invasion of the lamina propria on biopsy had tu mor extending outside the bladder in 15 (27%) of 55 cases. Patients with in vasion of the muscularis propria on biopsy had tumor extending outside the bladder in 47 (49%) of 96 cases, including nodal metastasis in 22 (23%) of 96 cases. Overall, bladder biopsy underestimated the true extent of the dis ease in 78 (46%) of 169 cases. Conclusions. Using either the WHO/ISUP (1998) classification or the traditi onal three-grade system, the histologic grade of the biopsy specimen is a f airly good predictor of the final histologic grade. The preoperative biopsy tends to understage bladder cancer. Patients with muscularis propria invas ion demonstrated by biopsy have a significantly higher risk of non-organ-co nfined disease than those with lamina propria invasion. UROLOGY 57: 1063-10 67, 2001. (C) 2001, Elsevier Science Inc.