Establishment of enzyme immunoassay for measuring serum sultopride levels

Citation
T. Someya et al., Establishment of enzyme immunoassay for measuring serum sultopride levels, THER DRUG M, 23(3), 2001, pp. 277-281
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology,"Pharmacology & Toxicology
Journal title
THERAPEUTIC DRUG MONITORING
ISSN journal
0163-4356 → ACNP
Volume
23
Issue
3
Year of publication
2001
Pages
277 - 281
Database
ISI
SICI code
0163-4356(200106)23:3<277:EOEIFM>2.0.ZU;2-7
Abstract
Measurement of serum sultopride levels was performed using an enzyme immuno assay. Little or no cross-reactivity with metabolites of sultopride and oth er drugs was found. The results of reproducibility, recovery, and dilution testing were all good enough for clinical use, A comparison between the mea surement values of this method (y) with that of high-performance liquid chr omatography (x) showed high correlation (n = 211, r = 0.991, p < 0.0001, y = 0.99x + 107.5). In a comparison between the sultopride dose and serum lev els in 161 patients, interindividual differences were large (19 times for s ame doses), implying that the serum level cannot be predicted from the dosa ge. The method was found to be reliable for serum level measurements of sul topride and useful for monitoring compliance and assessing the optimal dose .