Expression and acquisition of the conditioned place preference response tococaine in rats is blocked by selective inhibitors of the enzyme N-acetylated-alpha-linked-acidic dipeptidase (NAALADase)

Citation
Bs. Slusher et al., Expression and acquisition of the conditioned place preference response tococaine in rats is blocked by selective inhibitors of the enzyme N-acetylated-alpha-linked-acidic dipeptidase (NAALADase), SYNAPSE, 41(1), 2001, pp. 22-28
Citations number
53
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
SYNAPSE
ISSN journal
0887-4476 → ACNP
Volume
41
Issue
1
Year of publication
2001
Pages
22 - 28
Database
ISI
SICI code
0887-4476(200107)41:1<22:EAAOTC>2.0.ZU;2-J
Abstract
In this study we examined the effect of 2-(phosphonomethyl)pentanedioic aci d (2-PMPA) and GPI 5693, selective inhibitors of the enzyme N-Acetylated-al pha -Linked-Acidic Dipeptidase (NAALADase; glutamate carboxypeptidase II; E C no. 3.4.17.21), which cleaves glutamate from the dipeptide N-acetyl-aspar tyl-glutamate (NAAG), on the conditioned place preference (CPP) response to cocaine in male rats. The i.p. administration of 15 mg/kg of cocaine produ ced a significant CPP response. The acquisition and expression of the CPP r esponse to cocaine was blocked by the i.p. administration of 100 mg/kg of 2 -PMPA and the p.o. administration of 30 mg/kg of GPI 5693. In contrast, nei ther 2-PMPA nor GPI 5693 produced a CPP or conditioned place aversion respo nse when administered alone. Furthermore, neither 2-PMPA or GPI 5693 altere d the expression of the CPP response to food. These results indicate that N AALADase inhibitors block the incentive motivational value of cocaine, sugg esting that such agents may be of use in treating cue-induced craving in co caine addicts. Synapse 41:22-28, 2001. (C) 2001 Wiley-Liss, Inc.