Gemcitabine as single agent therapy in advanced non small cell lung cancerand quality of life in the elderly

Citation
V. Bianco et al., Gemcitabine as single agent therapy in advanced non small cell lung cancerand quality of life in the elderly, PANMIN MED, 43(1), 2001, pp. 15-19
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine
Journal title
PANMINERVA MEDICA
ISSN journal
0031-0808 → ACNP
Volume
43
Issue
1
Year of publication
2001
Pages
15 - 19
Database
ISI
SICI code
0031-0808(200103)43:1<15:GASATI>2.0.ZU;2-6
Abstract
Background. The aim of this study is to test the efficacy of gemcitabine as single agent therapy in advanced non-small cell lung cancer in the elderly by the evaluation of the clinical response, the survival increase and the quality of life. Methods. Nineteen patients (age > 65 years) with a PS >2, bearing an advanc ed non-small cell lung cancer (IIIb-IV) not treated with chemotherapy befor e, were charged between December 1996 and December 1998, Sixteen patients w ere treated with gemcitabine at the dose of 1000 mg/mq 1-8-15 every 28 days . CT scan, X-rays and skeletal scintigraphy were used in the evaluation of the therapeutic response. The toxicity was estimated by following WHO index es, The quality of life and the modification of the specific symptoms were estimated by particular tests (Spitzer Index, IADL, EORTC-LC13). Results, One complete response (6%), 4 partial responses (25%), 7 cases of illness stabilization (43%), 4 cases of illness progression, were shown, On e year of survival was found in 43% of cases with a 14 week of therapeutic response and a global survival ratio of 12.4 weeks. Only 2 cases (12.5) bf medium grade G3-leucopenia were found. All patients improved their quality of life (IADL and Spitzer indexes) with reduction of symptoms, (EORTC-LC13) and increase of self-agin and relationships. Conclusions. The effectiveness of gemcitabine as single agent therapy as no t yet been tested due to the scanty number of patients, nevertheless it mus t be considered in relation to the improvement of the patient's quality of life.