Axon-glia interactions and the domain organization of myelinated axons requires Neurexin IV/Caspr/Paranodin

Citation
Ma. Bhat et al., Axon-glia interactions and the domain organization of myelinated axons requires Neurexin IV/Caspr/Paranodin, NEURON, 30(2), 2001, pp. 369-383
Citations number
40
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEURON
ISSN journal
0896-6273 → ACNP
Volume
30
Issue
2
Year of publication
2001
Pages
369 - 383
Database
ISI
SICI code
0896-6273(200105)30:2<369:AIATDO>2.0.ZU;2-X
Abstract
Myelinated fibers are organized into distinct domains that are necessary fo r saltatory conduction. These domains include the nodes of Ranvier and the flanking paranodal regions where glial cells closely appose and form specia lized septate-like junctions with axons. These junctions contain a Drosophi la Neurexin IV-related protein, Caspr/Paranodin (NCP1). Mice that lack NCP1 exhibit tremor, ataxia, and significant motor paresis. In the absence of N CP1, normal paranodal junctions fail to form, and the organization of the p aranodal loops is disrupted. Contactin is undetectable in the paranodes, an d K+ channels are displaced from the juxtaparanodal into the paranodal doma ins. Loss of NCP1 also results in a severe decrease in peripheral nerve con duction velocity. These results show a critical role for NCP1 in the deline ation of specific axonal domains and the axon-glia interactions required fo r normal saltatory conduction.