In vitro antiplasmodial activity of extracts of Tristaniopsis species and identification of the active constituents: Ellagic acid and 3,4,5-trimethoxyphenyl-(6 '-O-galloyl)-O-beta-D-glucopyranoside
L. Verotta et al., In vitro antiplasmodial activity of extracts of Tristaniopsis species and identification of the active constituents: Ellagic acid and 3,4,5-trimethoxyphenyl-(6 '-O-galloyl)-O-beta-D-glucopyranoside, J NAT PROD, 64(5), 2001, pp. 603-607
Screening of plants from New Caledonia for antiplasmodial activity against
Plasmodium falciparum revealed that methanolic extracts of the leaves and b
ark of Tristaniopsis calobuxus, T. yateensis, and T. glauca inhibited the g
rowth of chloroquine-sensitive and -resistant clones. Ellagic acid and the
new compound 3,4,5-trimethoxyphenyl-(6 ' -O-galloyl)-O-beta -D-glucopyranos
ide were identified as the active constituents (IC50 0.5 and 3.2 muM, respe
ctively). The growth inhibition of both clones was comparable. The compound
s showed negligible or very low cytotoxicity to human skin fibroblasts and
Hep G2 cells when tested at concentrations ranging from 0.5 to 100 muM.