In vitro antiplasmodial activity of extracts of Tristaniopsis species and identification of the active constituents: Ellagic acid and 3,4,5-trimethoxyphenyl-(6 '-O-galloyl)-O-beta-D-glucopyranoside

Citation
L. Verotta et al., In vitro antiplasmodial activity of extracts of Tristaniopsis species and identification of the active constituents: Ellagic acid and 3,4,5-trimethoxyphenyl-(6 '-O-galloyl)-O-beta-D-glucopyranoside, J NAT PROD, 64(5), 2001, pp. 603-607
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
5
Year of publication
2001
Pages
603 - 607
Database
ISI
SICI code
0163-3864(200105)64:5<603:IVAAOE>2.0.ZU;2-V
Abstract
Screening of plants from New Caledonia for antiplasmodial activity against Plasmodium falciparum revealed that methanolic extracts of the leaves and b ark of Tristaniopsis calobuxus, T. yateensis, and T. glauca inhibited the g rowth of chloroquine-sensitive and -resistant clones. Ellagic acid and the new compound 3,4,5-trimethoxyphenyl-(6 ' -O-galloyl)-O-beta -D-glucopyranos ide were identified as the active constituents (IC50 0.5 and 3.2 muM, respe ctively). The growth inhibition of both clones was comparable. The compound s showed negligible or very low cytotoxicity to human skin fibroblasts and Hep G2 cells when tested at concentrations ranging from 0.5 to 100 muM.