Expression of estrogen receptor-alpha and -beta mRNAs in the male reproductive system of the rat as revealed by in situ hybridization

Citation
Cn. Mowa et T. Iwanaga, Expression of estrogen receptor-alpha and -beta mRNAs in the male reproductive system of the rat as revealed by in situ hybridization, J MOL ENDOC, 26(3), 2001, pp. 165-174
Citations number
39
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
JOURNAL OF MOLECULAR ENDOCRINOLOGY
ISSN journal
0952-5041 → ACNP
Volume
26
Issue
3
Year of publication
2001
Pages
165 - 174
Database
ISI
SICI code
0952-5041(200106)26:3<165:EOERA->2.0.ZU;2-8
Abstract
We mapped the cellular expression of estrogen receptor (ER) alpha and ER be ta mRNAs in the male reproductive system of the rat during development and adulthood by in situ hybridization. The expression patterns of ER alpha mRN A in the gonad, efferent duct and initial segment of the epididymis during the perinatal period were essentially similar to those of the adult: ER alp ha mRNA signals were expressed most intensely in the epithelia of the effer ent ducts and initial segment of the epididymis, and in the interstitial ce lls of the testis from the prenatal period to adulthood. However, ER alpha mRNA signals in the primordial epididymis and vas deferens during the prena tal period were confined to the outermost cellular layer of the ducts, wher eas thereafter they were only expressed weakly in the epithelium and stroma of the epididymis and moderately in the muscle layer of the vas deferens. ER beta signals were expressed intensely (1) in primordial germ and Sertoli cells only during the prenatal period, (2) in arterial walls in the adult testis, and (3) in the epithelium of the sex accessory glands from the peri natal period to adulthood. This report is the first to describe the cellula r distribution of ER mRNA in the male reproductive organs during the perina tal period, and complements and confirms earlier data on its distribution i n the adult. The broad expression of ERs in male reproductive organs sugges ts roles for estrogen in regulating tissue development and reproductive eve nts.