The effects of slice-selective excitation/refocusing in localized spectralediting with gradient-selected double-quantum coherence transfer

Authors
Citation
H. Lei et J. Dunn, The effects of slice-selective excitation/refocusing in localized spectralediting with gradient-selected double-quantum coherence transfer, J MAGN RES, 150(1), 2001, pp. 17-25
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis","Physical Chemistry/Chemical Physics
Journal title
JOURNAL OF MAGNETIC RESONANCE
ISSN journal
1090-7807 → ACNP
Volume
150
Issue
1
Year of publication
2001
Pages
17 - 25
Database
ISI
SICI code
1090-7807(200105)150:1<17:TEOSEI>2.0.ZU;2-N
Abstract
Spectral editing using gradient-selected double-quantum filtering (DQF) wit h PRESS localization has been used for selective observation of metabolites in vivo. In previous studies using localized DQF sequences, it is generall y assumed that the slice-selective pulses used in the sequence have no role s in coherence transfer, and do not interfere with DQE. To validate this as sumption, the effects of slice-selective excitation/refocusing on DQF were investigated in DQF lactate editing sequences combined with PRESS localizat ion. Contrary to the previous assumption, the results show that, due to che mical shift displacement artifact and J coupling, slice selection in DQF do es interfere with coherence transfer, affecting both the accuracy of spatia l localization and the detection sensitivity adversely. In the case of lact ate editing, the effects of this interference can be accounted for simply b y adjusting the strength of the slice-selection gradients and by using narr owband slice-selective refocusing pulses. (C) 2001 Academic Press.