RCAS1 antigen is highly expressed in extramammary Paget's disease and in advanced stage squamous cell carcinoma of the skin

Citation
H. Takahashi et al., RCAS1 antigen is highly expressed in extramammary Paget's disease and in advanced stage squamous cell carcinoma of the skin, J DERMA SCI, 26(2), 2001, pp. 140-144
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Dermatology
Journal title
JOURNAL OF DERMATOLOGICAL SCIENCE
ISSN journal
0923-1811 → ACNP
Volume
26
Issue
2
Year of publication
2001
Pages
140 - 144
Database
ISI
SICI code
0923-1811(200106)26:2<140:RAIHEI>2.0.ZU;2-R
Abstract
Receptor-binding cancer antigen expressed on SiSo cells (RCAS1). which is a type II membrane protein expressed on cervical carcinoma cells, induces ap optosis in RCAS1 receptor expressing cells. RCAS1 is thus presumed to prote ct tumor cells from immune surveillance by infiltrating RCAS1 receptor-posi tive immunocytes (Sonoda et al. Int J Oncol 1995; 6: 1899-1903; Nakashima e t al. Nature Med 1999; 5: 938-942). We performed immunohistochemical analys is of RCAS1 expression in various skin tumors. RCAS1 was not detected in no rmal human epidermis. One of 21 seborrheic keratosis (4.8%), one of 12 acti nic keratosis (8.3%), two of 16 keratoacanthomas (12.5%). and two of 14 bas al cell carcinomas (14.2%) expressed RCAS1. RCAS1 was not detected in Bowen 's disease (0/17). RCAS1 was positive in 45 of 61 (73.8%) squamous cell car cinomas. Interestingly, the expression of RCAS1 was mostly correlated with clinical stages of squamous cell carcinoma. It was found that 46.1% of stag e I, 61.1% of stage II, 85.7% of stage III. and 83.3% of stage IV squamous cell carcinomas were RCAS1-positive. In addition, RCAS1 was found to be hig hly expressed ill extramammary Paget's disease. Fifty nine of 63 extramamma ry Paget's disease samples (93.7%) were positive for RCAS1. Fifty eight (92 %) showed co-expression of RCAS1 and carcinoembryonic antigen (CEA). While two of 24 cases of melanoma (8.3%) expressed RCAS1 antigen, none of 20 case s of nevus pigmentosus showed positive staining. These results indicate tha t RCAS1 is a highly sensitive marker for extramammary Paget's disease. RCAS 1 is also expressed in various skin tumors including squamous cell carcinom a, where positive correlation with clinical staging was documented. (C) 200 1 Elsevier Science Ireland Ltd. All rights reserved.