Background and aims-Body gastritis caused by Helicobacter pylori infection
appears to inhibit gastric acid secretion. The aim of this study was to det
ermine the effects of H pylori infection on gastric acid secretion and clar
ify its mechanisms with reference to interleukin 1 beta (IL-1 beta).
Methods-(1) Mongolian gerbils were inoculated orally with H pylori. Before,
six, and 12 weeks after inoculation, serum gastrin levels, gastric acid ou
tput, and IL-1 beta mRNA levels in the gastric mucosa were determined. Path
ological changes were also determined according to the updated Sydney syste
m. (2) Effects of recombinant human IL-1 receptor antagonist (rhIL-1ra) on
gastric acid output and serum gastrin levels were also determined.
Results-(1) Scores for activity and inflammation of gastritis and serum gas
trin levels were significantly increased, and gastric acid output was signi
ficantly decreased six and 12 weeks after inoculation with H pylori. IL-1 b
eta mRNA levels in the gastric mucosa were also elevated six and 12 weeks a
fter inoculation with H pylori. (2) Acid output and serum gastrin levels in
the infected groups returned to control levels after rhIL-1ra injection.
Conclusions-Gastric acid secretion is decreased and serum gastrin levels ar
e increased in Mongolian gerbils infected with H pylori. This change in gas
tric acid secretion appears to be mediated by IL-1 beta induced by H pylori