Effects of Helicobacter pylori infection on gastric acid secretion and serum gastrin levels in Mongolian gerbils

Citation
M. Takashima et al., Effects of Helicobacter pylori infection on gastric acid secretion and serum gastrin levels in Mongolian gerbils, GUT, 48(6), 2001, pp. 765-773
Citations number
53
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology","da verificare
Journal title
GUT
ISSN journal
0017-5749 → ACNP
Volume
48
Issue
6
Year of publication
2001
Pages
765 - 773
Database
ISI
SICI code
0017-5749(200106)48:6<765:EOHPIO>2.0.ZU;2-N
Abstract
Background and aims-Body gastritis caused by Helicobacter pylori infection appears to inhibit gastric acid secretion. The aim of this study was to det ermine the effects of H pylori infection on gastric acid secretion and clar ify its mechanisms with reference to interleukin 1 beta (IL-1 beta). Methods-(1) Mongolian gerbils were inoculated orally with H pylori. Before, six, and 12 weeks after inoculation, serum gastrin levels, gastric acid ou tput, and IL-1 beta mRNA levels in the gastric mucosa were determined. Path ological changes were also determined according to the updated Sydney syste m. (2) Effects of recombinant human IL-1 receptor antagonist (rhIL-1ra) on gastric acid output and serum gastrin levels were also determined. Results-(1) Scores for activity and inflammation of gastritis and serum gas trin levels were significantly increased, and gastric acid output was signi ficantly decreased six and 12 weeks after inoculation with H pylori. IL-1 b eta mRNA levels in the gastric mucosa were also elevated six and 12 weeks a fter inoculation with H pylori. (2) Acid output and serum gastrin levels in the infected groups returned to control levels after rhIL-1ra injection. Conclusions-Gastric acid secretion is decreased and serum gastrin levels ar e increased in Mongolian gerbils infected with H pylori. This change in gas tric acid secretion appears to be mediated by IL-1 beta induced by H pylori infection.