Microsatellite instability is infrequent in medullary breast cancer

Citation
Sc. Lee et al., Microsatellite instability is infrequent in medullary breast cancer, AM J CLIN P, 115(6), 2001, pp. 823-827
Citations number
43
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Volume
115
Issue
6
Year of publication
2001
Pages
823 - 827
Database
ISI
SICI code
Abstract
Microsatellite instability (MSI), characterized by contraction or expansion in microsatellite length or short tandem repents compared with germline le ngths, is found in 85% to 90% of colon cancer arising in hereditary nonpoly posis colorectal cancer families, These cancers commonly have characteristi c histologic appearances, including medullary features with intense lymphoi d infiltrates. In pancreatic cancel; a rare medullary: histologic subtype m ore often demonstrates MSI than the more common adenocarcinoma subtype. We hypothesized that the medullary histologic pattern might correlate with MSI in additional tumor types ann analyzed 8 cases of typical and a typical me dullary carcinoma of the breast. Tumor and normal DNA was extracted from pa raffinized tissue blocks of tumor and histologically uninvolved axillary I? mph nodes, respectively We analyzed the tumors for instability in 5 primar y (BAT25, BA726, D17S250, D5S346, D2S123) and 3 alternative (BAT40, D18S55, D18S58) microsatellites recommended at the National Cancer institute-spons ored conference for diagnosis of MSI in colorectal cancer AII 8 rumors M er e microsatellite stable at the 8 loci, suggesting that MSI is not commonly, associated with medullary or atypical medullary breast carcinoma, in contr ast with the reported association with medullary tumors of the colon and pa ncreas.