When to start highly active antiretroviral therapy in chronically HIV-infected patients: evidence from the ICONA study

Citation
Ac. Lepri et al., When to start highly active antiretroviral therapy in chronically HIV-infected patients: evidence from the ICONA study, AIDS, 15(8), 2001, pp. 983-990
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
AIDS
ISSN journal
0269-9370 → ACNP
Volume
15
Issue
8
Year of publication
2001
Pages
983 - 990
Database
ISI
SICI code
0269-9370(20010525)15:8<983:WTSHAA>2.0.ZU;2-I
Abstract
Objectives: To compare the response to highly active antiretroviral therapy (HAART) in individuals starting HAART at different CD4 cell counts. Design: The mean increase in CD4 cell count and rate of virological failure after commencing HAARTwere measured in antiretroviral-naive patients(1421) in a large, nonrandomized multicentre, observational study in Italy (ICONA ). Clinical endpoints were a Iso evaluated in a subset of patients who star ted HAARTwith a very low CD4 cell count. Results: After 96 weeks of therapy, the mean rise in CD4 cell count was 280 , 281 and 186 x 10(6) cells/l in patients starting HAART with a CD4 cell co unt < 200, 201-350 and > 350 x 10(6) cells/l, respectively. Patients starti ng HAART with a CD4 cell count < 200 x 10(6) cells/l tended to have a highe r risk of subsequent virological failure [relative hazard (RH), 1.15; 95% c onfidence interval (CI), 0.93-1.42] compared with patients starting with > 350 x 10(6) cells/l. There was no difference in risk between the 201-350 an d the > 350 x 10(6) cells/l groups (RH, 1.0; 95% CI, 0.79-1.29). The incide nce of new AIDS-defining diseases/death in patients who started HAART with a CD4 count < 50 was 0.03/person-year (95% CI, 0.10-0.33) during the time i n which the patient's CD4 cell count had been raised to > 200 x 10(6) cells /l. Conclusions: There was no clear immunological or virological advantage in s tarting HAART at a CD4 cell count > 350 rather than at 200-350 x 10(6) cell s/l. The increase in CD4 cells restored by HAART is meaningful in that they are associated with reduced risk of disease/death. (C) 2001 Lippincott Wil liams & Wilkins.