Cloning and characterization of a human lysyl oxidase-like 3 gene (hLOXL3)

Citation
Y. Huang et al., Cloning and characterization of a human lysyl oxidase-like 3 gene (hLOXL3), MATRIX BIOL, 20(2), 2001, pp. 153-157
Citations number
12
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biochemistry & Biophysics
Journal title
MATRIX BIOLOGY
ISSN journal
0945-053X → ACNP
Volume
20
Issue
2
Year of publication
2001
Pages
153 - 157
Database
ISI
SICI code
0945-053X(200104)20:2<153:CACOAH>2.0.ZU;2-0
Abstract
Using the PCR primers generated from human expressed sequence tag (EST), th e cDNA of lysyl oxidase-like gene 3 (LOXL3), a new member of human lysyl ox idases gene family, was cloned from the human fetal brain mRNA. The predict ed amino acid sequence of the hLOXL3 gene was highly homologous to mLOR2. B ioinformatics analysis shows that hLOXL3 protein is also a member of the sc avenger receptor cysteine-rich family, which contains a 25 amino acids sign al peptide. The hLOXL3 gene was mapped to human 2p13 locus by BLAST search and at least 14 exons were found. Expression of the hLOXL3 gene was detecte d in several human tissues and especially high in spleen and testis. (C) 20 01 Elsevier Science B.V./International Society of Matrix Biology. All right s reserved.