Evidence for in-vivo transfer of mecA DNA between strains of Staphylococcus aureus

Citation
Clc. Wielders et al., Evidence for in-vivo transfer of mecA DNA between strains of Staphylococcus aureus, LANCET, 357(9269), 2001, pp. 1674-1675
Citations number
5
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
LANCET
ISSN journal
0140-6736 → ACNP
Volume
357
Issue
9269
Year of publication
2001
Pages
1674 - 1675
Database
ISI
SICI code
0140-6736(20010526)357:9269<1674:EFITOM>2.0.ZU;2-Q
Abstract
Staphylococcus aureus is thought to have acquired mecA DNA by horizontal tr ansfer. DNA fingerprints made by restriction nucleases that cut certain seq uences of DNA are used to compare complete genomes or particular genes betw een bacteria. We isolated an epidemic mecA(-) meticillin-susceptible S aure us genotype and, subsequently, a rare isogeneic mecA(+) meticillin-resistan t S aureus (MRSA) genotype from a neonate who had never been in contact wit h MRSA. This MRSA contained mecA DNA that was identical to that in a coagul ase-negative staphylococcal strain isolated from this patient, but differen t from other MRSA genotypes. We believe that this MRSA was formed in vivo b y horizontal transfer of the mecA DNA between two staphylococcal species.