Ji. Tanaka et al., Synthesis of (S)-ibuprofen via enantioselective degradation of racemic ibuprofen with an isolated yeast, Trichosporon cutaneum KPY 30802, in an interface bioreactor, J BIOSCI BI, 91(3), 2001, pp. 314-315
An interface bioreactor was used for the enantioselective degradation of (R
S)-ibuprofen (IBU). An isolated yeast, Trichosporon cutaneum KPY 30802, pre
ferentially degraded (R)-IBU to accumulate (S)-isomer. The addition of hydr
oquinone (10 mM) into a hydrophilic carrier was effective for the elevation
of enantiomeric excess and the repression of excess degradation of (S)-IBU
(E value, 9.3).