Synthesis of (S)-ibuprofen via enantioselective degradation of racemic ibuprofen with an isolated yeast, Trichosporon cutaneum KPY 30802, in an interface bioreactor

Citation
Ji. Tanaka et al., Synthesis of (S)-ibuprofen via enantioselective degradation of racemic ibuprofen with an isolated yeast, Trichosporon cutaneum KPY 30802, in an interface bioreactor, J BIOSCI BI, 91(3), 2001, pp. 314-315
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
ISSN journal
1389-1723 → ACNP
Volume
91
Issue
3
Year of publication
2001
Pages
314 - 315
Database
ISI
SICI code
1389-1723(200103)91:3<314:SO(VED>2.0.ZU;2-Y
Abstract
An interface bioreactor was used for the enantioselective degradation of (R S)-ibuprofen (IBU). An isolated yeast, Trichosporon cutaneum KPY 30802, pre ferentially degraded (R)-IBU to accumulate (S)-isomer. The addition of hydr oquinone (10 mM) into a hydrophilic carrier was effective for the elevation of enantiomeric excess and the repression of excess degradation of (S)-IBU (E value, 9.3).