Activation of the lectin complement pathway by ficolins

Citation
M. Matsushita et al., Activation of the lectin complement pathway by ficolins, INT IMMUNO, 1(3), 2001, pp. 359-363
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
INTERNATIONAL IMMUNOPHARMACOLOGY
ISSN journal
1567-5769 → ACNP
Volume
1
Issue
3
Year of publication
2001
Pages
359 - 363
Database
ISI
SICI code
1567-5769(200103)1:3<359:AOTLCP>2.0.ZU;2-6
Abstract
Mannose-binding lectin (MBL), a serum lectin specific for mannose or N-acet ylglucosamine (GlcNAc), which contains both a collagen-like domain and a ca rbohydrate-recognition domain (CRD). plays a role in innate immunity by act ing as an opsonin and activating complement in association with MEL-associa ted serine protease (MASP) via the lectin pathway. Another type of GlcNAc-b inding lectins termed "ficolins" exist in serum. They are characterized by the presence of both a collagen-like domain and a fibrinogen-like domain. I nvestigations of two types Of human serum ficolins, ficolin/P35 and Hakata antigen, revealed that they are associated with MASPs and sMAP, a truncated protein of MASP-2, and activate complement. These findings indicate that, like MEL. serum ficolins an collagenous lectins capable of activating the l ectin pathway and thus have a role in innate immunity. (C) 2001 Elsevier Sc ience B.V. All rights reserved.