Dietary factors and lung cancer risk in Japanese: with special reference to fish consumption and adenocarcinomas

Citation
T. Takezaki et al., Dietary factors and lung cancer risk in Japanese: with special reference to fish consumption and adenocarcinomas, BR J CANC, 84(9), 2001, pp. 1199-1206
Citations number
48
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
BRITISH JOURNAL OF CANCER
ISSN journal
0007-0920 → ACNP
Volume
84
Issue
9
Year of publication
2001
Pages
1199 - 1206
Database
ISI
SICI code
0007-0920(20010504)84:9<1199:DFALCR>2.0.ZU;2-X
Abstract
To investigate risk modification for lung cancer with diet in Japanese, we conducted a hospital-based case-control study and evaluated variation in in fluence with the histological type. We recruited 367 male and 240 female ca ses with adenocarcinomas, and 381 male and 57 female cases with squamous ce ll and small cell carcinomas. Controls comprised 2964 male and 1189 female cancer-free outpatients matched for sex and age with the cases. Odds ratios (ORs) and their 95% confidence intervals (Cls) for lung cancer were calcul ated with adjustment for potential confounding factors, using an unconditio nal logistic model. We found decreased ORs for adenocarcinomas in both male s (OR = 0.51, 95% CI 0.31-0.84) and females (OR = 0.48, 95% CI 0.24-0.94) w ho consumed cooked/raw fish, but not dried/salted fish at the highest quart ile frequency, compared with the lowest. Soybean curd consumption was assoc iated with a decreased OR for female adenocarcinomas. Decreased ORs for squ amous cell and small cell carcinomas were observed in males with frequent c onsumption of raw and green vegetables, fruit and milk, but consumption of carrot, pumpkin, egg and coffee was associated with increased ORs. This stu dy suggests cooked/raw fish consumption lowers the risk of adenocarcinoma o f the lung in Japanese. (C) 2001 Cancer Research Campaign.