Increased gastric acid secretion after Helicobacter pylori eradication maybe a factor for developing reflux oesophagitis

Citation
T. Koike et al., Increased gastric acid secretion after Helicobacter pylori eradication maybe a factor for developing reflux oesophagitis, ALIM PHARM, 15(6), 2001, pp. 813-820
Citations number
41
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology,"da verificare
Journal title
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
ISSN journal
0269-2813 → ACNP
Volume
15
Issue
6
Year of publication
2001
Pages
813 - 820
Database
ISI
SICI code
0269-2813(200106)15:6<813:IGASAH>2.0.ZU;2-U
Abstract
Background: The role of acid secretion in reflux oesophagitis which may dev elop after H. pylori eradication is not well known. Aim: To investigate the participation of altered gastric acid secretion and the presence of hiatal hernia in the development of reflux oesophagitis af ter eradication therapy for H. pylori. Subjects and Methods: A total of 105 patients with H. pylori infection, but without reflux oesophagitis at the time of eradication therapy, were follo wed prospectively for 7 months after the clearance of this microorganism. G astric acid secretion was assessed by endoscopic gastrin test, and the pres ence of hiatal hernia by endoscopy. Results: Reflux oesophagitis developed in 11 out of 105 (10.5%) patients wh en examined at 7 months after the eradication therapy. The incidence was co rrelated significantly with the increase in gastric acid secretion after th e eradication of H. pylori, and was significantly higher in the patients wi th hiatal hernia (20%) than in those without it (0%). Conclusions: Increased acid secretion after H. pylori eradication is an imp ortant risk factor of reflux oesophagitis, especially in patients with hiat al hernia.