Periradicular infiltration for sciatica - A randomized controlled trial

Citation
J. Karppinen et al., Periradicular infiltration for sciatica - A randomized controlled trial, SPINE, 26(9), 2001, pp. 1059-1067
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurology
Journal title
SPINE
ISSN journal
0362-2436 → ACNP
Volume
26
Issue
9
Year of publication
2001
Pages
1059 - 1067
Database
ISI
SICI code
0362-2436(20010501)26:9<1059:PIFS-A>2.0.ZU;2-7
Abstract
Study Design. A randomized, double-blind trial was conducted. Objectives. To test the efficacy of periradicular corti costeroid injection for sciatica. Summary of Background Data. The efficacy of epidural corticosteroids for sc iatica is controversial. Periradicular infiltration is a targeted technique , but there are no randomized controlled trials of its efficacy. Methods. In this study 160 consecutive, eligible patients with sciatica who had unilateral symptoms of 1 to 6 months duration, and who never underwent surgery were randomized for double-blind injection with methylprednisolone bupivacaine combination or saline. Objective and self-reported outcome par ameters and costs were recorded at baseline, at 2 and 4 weeks, at 3 and 6 m onths, and at 1 year. Results. Recovery was better in the steroid group at 2 weeks for leg pain ( P = 0.02), straight leg raising (P = 0.03), lumbar flexion (P = 0.05), and patient satisfaction (P = 0.03). Back pain was significantly lower in the s aline group at 3 and 6 months (P = 0.03 and 0.002, respectively), and leg p ain at 6 months (13.5, P = 0.02). Sick leaves and medical costs were simila r for both treatments, except for cost of therapy visits and drugs at 4 wee ks, which were in favor of the steroid injection (P = 0.05 and 0.005, respe ctively). By 1 year, 18 patients in the steroid group and 15 in the saline group underwent surgery. Conclusions. improvement during the follow-up period was found in both the methylprednisolone and saline groups. The combination of methylprednisolone and bupivacaine seems to have a short-term effect, but at 3 and 6 months, the steroid group seems to experience a "rebound" phenomenon.