Pneumocystis carinii pneumonia with an atypical granulomatous response in a patient with chronic lymphocytic leukemia

Citation
Y. Oki et al., Pneumocystis carinii pneumonia with an atypical granulomatous response in a patient with chronic lymphocytic leukemia, LEUK LYMPH, 41(3-4), 2001, pp. 435-438
Citations number
9
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Onconogenesis & Cancer Research
Journal title
LEUKEMIA & LYMPHOMA
ISSN journal
1042-8194 → ACNP
Volume
41
Issue
3-4
Year of publication
2001
Pages
435 - 438
Database
ISI
SICI code
1042-8194(200104)41:3-4<435:PCPWAA>2.0.ZU;2-K
Abstract
We have recently seen a patient who developed Pneumocystis carinii pneumoni a (PCP) in the course of treatment for chronic lymphocytic leukemia (CLL). This case showed uncommon pathological findings with extensive formation of granulomatous lesions. Despite advanced CLL associated with poor B-cell fu nction, she responded well to anti-PCP treatment. In contrast to B-cell fun ction, the T-cell functions were well preserved in vitro, and the numbers o f peripheral CD4- and CD8-positive cells were normal, and T-cell functions were normal. These findings suggest that the production of granulomatous le sions to PCP may have been associated with the patients' immune status, and that it may constitute a good indicator in PCP infection in patients with underlying hematological malignancy.