We have recently seen a patient who developed Pneumocystis carinii pneumoni
a (PCP) in the course of treatment for chronic lymphocytic leukemia (CLL).
This case showed uncommon pathological findings with extensive formation of
granulomatous lesions. Despite advanced CLL associated with poor B-cell fu
nction, she responded well to anti-PCP treatment. In contrast to B-cell fun
ction, the T-cell functions were well preserved in vitro, and the numbers o
f peripheral CD4- and CD8-positive cells were normal, and T-cell functions
were normal. These findings suggest that the production of granulomatous le
sions to PCP may have been associated with the patients' immune status, and
that it may constitute a good indicator in PCP infection in patients with
underlying hematological malignancy.