Apolipoprotein B, ratio of total cholesterol to HDL-C, and blood pressure in abdominally obese white and black American women

Citation
Is. Okosun et al., Apolipoprotein B, ratio of total cholesterol to HDL-C, and blood pressure in abdominally obese white and black American women, J HUM HYPER, 15(5), 2001, pp. 299-305
Citations number
44
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
JOURNAL OF HUMAN HYPERTENSION
ISSN journal
0950-9240 → ACNP
Volume
15
Issue
5
Year of publication
2001
Pages
299 - 305
Database
ISI
SICI code
0950-9240(200105)15:5<299:ABROTC>2.0.ZU;2-A
Abstract
Objective: To compare the association of apolipoprotein a (ApoB) and total cholesterol to high-density lipoprotein cholesterol (TC/HDL) with blood pre ssure in abdominally obese white and black American women. We also sought t o determine if there are ethnic differences in blood pressure values that c ould be explained by differences in mean values of ApoB and TC/HDL, Methods: Data (n = 1844) from the Third US National Health and Nutrition Ex amination Survey were used in this study. Abdominal obesity was defined as waist circumference (WC) of greater than or equal to 88 cm or having WC gre ater than what was expected as predicted from residuals obtained from linea r regression of WC on BMI, Bi-variate Pearson's correlation analysis was us ed to quantify the degree of association of ApoB and TC/HDL with blood pres sure and other lipids. Multiple linear regression analysis was used to asse ss the independent contribution of ApoB and TC/HDL to blood pressure, adjus ting for age, total cholesterol, alcohol intake, and smoking. To determine ethnic differences in blood pressure values associated with ApoB or TC/HDL, dummy variables were used to compare blacks with whites fitted in multiple regression models, while adjusting for age, total cholesterol, alcohol int ake and smoking. Results: Elevated ApoB was positively associated with diastolic and systoli c blood pressure (DBP/SBP) in blacks and whites, independent of age, total cholesterol, alcohol intake and smoking (P < 0.01). Elevated TC/HDL was als o positively associated with increased DBP and SEP in whites (P < 0.05), Fo r the same value of ApoB and TC/HDL whites had higher values of DBP and SEP than blacks, adjusting for confounding variables. Conclusions: Compared with TC/HDL, ApoB was more strongly associated with D BP and SEP in both abdominally obese white and black women. Since ApoB is a ssociated with hypertension, the combination of elevated ApoB and hypertens ion may identify a group of patients with more marked risk of vascular dise ase, thus, warranting further investigation.