Assessment of prognostic factors in follicular lymphoma patients

Citation
E. Kondo et al., Assessment of prognostic factors in follicular lymphoma patients, INT J HEMAT, 73(3), 2001, pp. 363-368
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology
Journal title
INTERNATIONAL JOURNAL OF HEMATOLOGY
ISSN journal
0925-5710 → ACNP
Volume
73
Issue
3
Year of publication
2001
Pages
363 - 368
Database
ISI
SICI code
0925-5710(200104)73:3<363:AOPFIF>2.0.ZU;2-9
Abstract
Prognostic factors, including clinical, biological, and histological parame ters, were assessed for 94 patients with follicular lymphomas at our instit ute. Follicular lymphomas constituted 7.7% (94/1208) of malignant lymphomas in this study. Eighteen patients were diagnosed with stage I follicular ly mphoma, 20 with stage 11.23 with stage III, and 33 with stage IV. The cases of follicular lymphoma were subclassified as: follicular small cleaved cel l lymphoma (FSC) in 20 cases, follicular mixed cell lymphoma (FMX) in 59 ca ses, and follicular large cell lymphoma (FLC) in 15 cases. The patients com prised 49 men and 45 women with a median age of 54 years (range, 25-84 year s). The complete response rate was 76.5%, and the median survival time was 13 years. The expected 10-year overall survival and event-free survival rat es were 61.9% and 38.2%, respectively. Univariate analysis identified the f actors associated with poor survival as elevated serum lactate dehydrogenas e (LDH) level (P < .0001), age of >60 (P < .0001). Ann Arbor stage III/IV ( P < .01), and Eastern Cooperative Oncology Group performance status (PS) of 2 to 4 (P = .048). Multivariate analysis showed that LDH, age, and PS were independent predictors. After application of the International Prognostic Index (IPI), the 10-year survival rates for the low-risk, low-intermediate risk, high-intermediate risk and high-risk groups were 80.4%, 48.7%, 21.9%. and 0.0%, respectively. The differences among these groups were significan t at P < .01. The IPI for aggressive non-Hodgkin's lymphoma was found to be applicable to survival prediction for Japanese follicular lymphoma patient s. (C) 2001 The Japanese Society of Hematology.