Hydrosalpinx treated with extended doxycycline does not compromise the success of in vitro fertilization

Citation
Bs. Hurst et al., Hydrosalpinx treated with extended doxycycline does not compromise the success of in vitro fertilization, FERT STERIL, 75(5), 2001, pp. 1017-1019
Citations number
4
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Reproductive Medicine","da verificare
Journal title
FERTILITY AND STERILITY
ISSN journal
0015-0282 → ACNP
Volume
75
Issue
5
Year of publication
2001
Pages
1017 - 1019
Database
ISI
SICI code
0015-0282(200105)75:5<1017:HTWEDD>2.0.ZU;2-2
Abstract
Objective: To determine if extended treatment with doxycycline before and a fter an in vitro fertilization (IVF) procedure can minimize the detrimental effect of a hydrosalpinx. Design: Retrospective analysis. Setting: University IVF program. Patient(s): Patients undergoing IVF, including 17 with a hydrosalpinx, 25 w ith adhesions or proximal tubal occlusion, and 22 with endometriosis or une xplained infertility. Intervention(s): Women with a documented hydrosalpinx were prescribed doxyc ycline 100 mg twice daily starting 1 week before expected retrieval and con tinued until 6 days after retrieval. No antibiotics were prescribed in the other groups. Main Outcome Measure(s): Implantation rates and IVF outcomes. Result(s): Implantation rates were 30% for the doxycycline-treated group of patients with a hydrosalpinx, 27% for the group with tubal occlusion/adhes ion, and 24% for the group with endometriosis or unexplained infertility. E ight (47%) of 17 patients with a hydrosalpinx had a live birth, compared wi th 11 (44%) of 25 for the group with tubal occlusion/adhesion and 12 (55%) of 22 for the group with endometriosis/unexplained infertility. There were no differences between the groups in patient age, number of oocytes retriev ed, fertilization rate, or number of blastomeres of the transferred embryos . Conclusion(s): No detrimental effect of a hydrosalpinx was evident for pati ents treated with extended doxycycline. Tremendous cost savings can be real ized if treatment with 2 weeks of an inexpensive antibiotic provides outcom es comparable to surgical correction of a hydrosalpinx before IVF. (Fertil Steril(R) 2001;75: 1017-19. (C) 2001 by American Society for Reproductive M edicine.).