Topiramate is an antiepileptic agent, which is being investigated as a mood
-stabilizer. Three obese individuals with DSM-IV bipolar I disorder and typ
e II diabetes mellitus received topiramate treatment in combination with an
tipsychotics and valproate or carbamazepine. In addition to improved mood s
tability, these individuals lost between 16 to 20.5% of their pre-topiramat
e body weight and also achieved significant glycemic control. (C) 2001 Edit
ions scientifiques et medicales Elsevier SAS.