Clinical characteristics of familial versus sporadic alcoholism in a sample of male and female patients

Citation
F. Limosin et al., Clinical characteristics of familial versus sporadic alcoholism in a sample of male and female patients, EUR PSYCHIA, 16(3), 2001, pp. 151-156
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Psychiatry,"Clinical Psycology & Psychiatry
Journal title
EUROPEAN PSYCHIATRY
ISSN journal
0924-9338 → ACNP
Volume
16
Issue
3
Year of publication
2001
Pages
151 - 156
Database
ISI
SICI code
0924-9338(200104)16:3<151:CCOFVS>2.0.ZU;2-W
Abstract
Presence of a family history of alcoholism may predict clinical characteris tics in affected subjects, such as an earlier age at onset. More frequent a nd severe social maladjustment and somatic complications are also regularly cited for familial alcoholism, although subject to many other confusing fa ctors. We analysed the clinical specificities of 79 alcohol-dependent inpat ients according to the absence versus presence of family history of alcohol ism. Patients were evaluated for lifetime psychiatric morbidity with the Di agnostic Interview for Genetic Studies (DIGS), for somatic complications wi th a systematic screening list, and first-degree relatives (N = 428) were a ssessed with the Family Inventory Schedule and Criteria (FISC). Age at onset and social complications were predicting familial versus spora dic alcoholism, even when considering censored data and/or interaction betw een variables. But differences became non-significant when excluding patien ts with antisocial personality. If age at onset effectively appears to be the most informative characterist ic for predicting familial versus sporadic alcoholism, it seems that it may be necessary in future studies to systematically take into account antisoc ial personality diagnosis, because of a probable contamination. (C) 2001 Ed itions scientifiques et medicales Elsevier SAS.