Dizocilpine but not ketamine reduces the volume of ischaemic damage after acute subdural haematoma in the rat

Citation
K. Uchida et al., Dizocilpine but not ketamine reduces the volume of ischaemic damage after acute subdural haematoma in the rat, EUR J ANAES, 18(5), 2001, pp. 295-302
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Aneshtesia & Intensive Care
Journal title
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
ISSN journal
0265-0215 → ACNP
Volume
18
Issue
5
Year of publication
2001
Pages
295 - 302
Database
ISI
SICI code
0265-0215(200105)18:5<295:DBNKRT>2.0.ZU;2-B
Abstract
Background and objective Increased glutamate concentration in the cerebrosp inal fluid has been reported in severely head-injured patients, suggesting that an excessive release of glutamate may be involved in the process of ne uronal damage. Ischaemic damage after subdural haematoma has been reported to be reduced by glutamate (N-methyl-D-aspartate: NMDA) receptor antagonist s such as dizocilpine and CGS 19755; even though these drugs were given 20- 30 min after insult. Excessive release of excitatory amino acids may produc e the neural damage after subdural haematoma and NMDA receptor antagonists may become valuable therapeutic drugs. This study compared the effects of k etamine and dizocilpine, on intracranial pressure and histopathological cha nges after acute subdural haematoma produced by an injection of autologous blood (150 muL) in rats. Methods The control (n=9), ketamine (n=9) and dizocilpine (n=9) groups, res pectively, received saline, ketamine (total dose: 210 mg kg(-1)) or dizocil pine (total dose: 1.0 mg kg(-1)) from 0.5 to 8 h after acute subdural haema toma, A silicone group (n=9) had the same volume of silicone injected subdu rally. Results The volume of ischaemic damage in the silicone group (1.3 +/- 1.2 m m(3)) was significantly smaller than in the control group (11.9 +/- 3.8 mm( 3)). Ketamine and dizocilpine did not increase intracranial pressure. Dizoc ilpine significantly decreased the volume of ischaemic damage (6.1 +/- 3.8 mm(3)). Ketamine failed to significantly decrease damage (7.8 +/- 5.0 mm(3) ). Conclusions These results suggest that the factors elicited by the dotted b lood contribute to the ischaemic damage after subdural haematoma, and that the glutamate receptor antagonist dizocilpine reduces the damage, while ket amine shows only a trend reduction of the damage.