Combined "mixed medullary-follicular" and "papillary" carcinoma of the thyroid with lymph node metastasis

Citation
M. Shimizu et al., Combined "mixed medullary-follicular" and "papillary" carcinoma of the thyroid with lymph node metastasis, ENDOCR PATH, 11(4), 2000, pp. 353-358
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
ENDOCRINE PATHOLOGY
ISSN journal
1046-3976 → ACNP
Volume
11
Issue
4
Year of publication
2000
Pages
353 - 358
Database
ISI
SICI code
1046-3976(200024)11:4<353:C"MA"C>2.0.ZU;2-0
Abstract
We report a case of combined "mixed medullary-follicular" and "papillary" c arcinoma of the thyroid that occurred in a 44-yr-old Japanese woman. The gr ossly single 3 cm tumor was histologically composed of both mixed medullary -follicular carcinoma and papillary carcinoma, which abutted against each o ther with a clear border between two components. Immunohistochemically, the component of medullary carcinoma was positive for calcitonin and carcinoem bryonic antigen (CEA), and the follicular carcinoma and papillary carcinoma components were positive for thyroglobulin. Lymph node metastasis was also noted. The patient has been alive without recurrence for 20 yr. To the bes t of our knowledge, this is the first reported case in the literature. We r eport this unique case of thyroid carcinoma and review related thyroid mali gnancies.