Infectious disease pathology

Citation
Gw. Procop et M. Wilson, Infectious disease pathology, CLIN INF D, 32(11), 2001, pp. 1589-1601
Citations number
115
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
CLINICAL INFECTIOUS DISEASES
ISSN journal
1058-4838 → ACNP
Volume
32
Issue
11
Year of publication
2001
Pages
1589 - 1601
Database
ISI
SICI code
1058-4838(20010601)32:11<1589:IDP>2.0.ZU;2-L
Abstract
The anatomic pathologist performs an important role in the diagnosis or exc lusion of infectious diseases. The morphologic interpretation of biopsies a nd cytologic preparations allows for the definitive establishment or exclus ion of a wide variety of diseases. Once the pathologist has determined that a disease is likely to be due to an infection and has characterized the in flammatory response, associated microorganisms or viral-associated cytopath ic effects should be recorded. Although some microorganisms or their cytopa thic effects may be clearly visible on routine hematoxylin and eosin-staine d sections, additional histochemical stains are often needed for their comp lete characterization. Highly specific molecular techniques, such as immuno histochemistry, in situ hybridization, and nucleic acid amplification, may be needed in certain instances to establish the diagnosis of infection. Thr ough appropriate morphologic diagnoses and interlaboratory communication an d collaboration, the anatomic pathologist contributes greatly to the diagno sis and treatment of infectious diseases.