Near-infrared topography with indocyanine green was used to measure regiona
l cerebral blood flow (rCBF) in the temporal lobes of infants. The mean rCB
F in infants without neural abnormality was 14.5 +/- 3.1 ml/100 g/min, and
the rCBFs in the frontotemporal, temporal, and occipito-temporal regions we
re 15.1 +/- 3.9, 15.4 +/- 3.3, and 14.6 +/- 3.3 ml/100 g/min, respectively.
Moreover, in one asphyxiated infant with infarction and one infant with su
bdural and intracerebellar hemorrhage, it was demonstrated that the area of
defective blood flow could be detected as well as it can by SPECT. This te
chnique makes it possible to estimate rCBF distribution in infants at the b
edside. Thus, in the future, evaluation of various neonatal illnesses shoul
d be feasible. (C) 2001 Academic Press.