Tissue-specific expression of an ornithine decarboxylase paralogue, XODC2,in Xenopus laevis

Citation
Y. Cao et al., Tissue-specific expression of an ornithine decarboxylase paralogue, XODC2,in Xenopus laevis, MECH DEVEL, 102(1-2), 2001, pp. 243-246
Citations number
7
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
MECHANISMS OF DEVELOPMENT
ISSN journal
0925-4773 → ACNP
Volume
102
Issue
1-2
Year of publication
2001
Pages
243 - 246
Database
ISI
SICI code
0925-4773(200104)102:1-2<243:TEOAOD>2.0.ZU;2-9
Abstract
Ornithine decarboxylase (ODC) is involved in the biosynthesis of polyamines and hence has been found in almost all types: of cells studied. Therefore it is frequently used as internal standard. We isolated a cDNA, XODC2, whic h! is a paralogue to ubiquitous ODC and expressed in a spatial and temporal manner during the early embryogenesis of Xenopus laevis. Expression of XOD C2 was first detected at the animal pole at stage 9. During neurula stages the signals were found both in the extreme anterior and posterior part of t he dorsal body axis. In tailbud stages the expression is further shifted to both the tail and head areas and gradually restricted to distinct tissues: forebrain, inner layer of epidermis of the head area, stomodeal-hypophysea l anlage, frontal gland, ear vesicle, branchial arches, the front tip of ne ural tube and proctodeum In addition, signals were also found in the inner layer of epidermis underneath the cement gland during early tailbud stages while in later tailbud stages signals were detected at the apical zone of t he cement gland. Comparative studies indeed could confirm that XODC1 in con trast to XODC2 is expressed ubiquitously throughout the whole embryos durin g early development of Xenopus laevis. (C) 2001 Elsevier Science Ireland Lt d. All rights reserved.