Early growth-response factor 1 and basic transcriptional element-binding protein 2 expression in cardiac allografts

Citation
Y. Wada et al., Early growth-response factor 1 and basic transcriptional element-binding protein 2 expression in cardiac allografts, J HEART LUN, 20(5), 2001, pp. 590-594
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
JOURNAL OF HEART AND LUNG TRANSPLANTATION
ISSN journal
1053-2498 → ACNP
Volume
20
Issue
5
Year of publication
2001
Pages
590 - 594
Database
ISI
SICI code
1053-2498(200105)20:5<590:EGF1AB>2.0.ZU;2-4
Abstract
Early growth-response factor 1 (Egr-1) and basic transcriptional element-bi nding protein 2 (BTEB2) are transcriptional factors that regulate multiple genes involved in phenotypic changes of smooth muscle cells (SMCs), one of the outstanding pathologic features of chronic cardiac allograft rejection. In this study, we used a heterotopic abdominal heart transplant model in m onkeys to evaluate the roles of these molecules in graft coronary vasculopa thy. We demonstrated that Egr-1 and BTEB2 are induced in vascular SMCs of r ejected cardiac allografts well before morphologic changes, such as intimal thickening. These findings suggest that expression of Egr-1 and BTEB2 is o ne of the initial events in allograft angiopathy.