Assessment of the temperature distribution during hyperthermia treatment by isolated extremity perfusion

Citation
J. Gantenberg et al., Assessment of the temperature distribution during hyperthermia treatment by isolated extremity perfusion, INT J HYPER, 17(3), 2001, pp. 189-206
Citations number
55
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF HYPERTHERMIA
ISSN journal
0265-6736 → ACNP
Volume
17
Issue
3
Year of publication
2001
Pages
189 - 206
Database
ISI
SICI code
0265-6736(200105/06)17:3<189:AOTTDD>2.0.ZU;2-1
Abstract
A finite-element model of the human leg is developed for the assessment of temperature distribution during hyperthermia treatment by isolated extremit y perfusion with a heart-lung-machine. The simulation comprises the true ge ometry, adequate perfusion models for the different parts of the extremity circulation in normal and tumour tissue, and the numerical procedure for th e solution of the partial differential heat balance equation used. The simu lation is validated using both experimental physiological and clinical data , and predicts temperature distributions and courses for various modificati ons of the hyperthermia procedure. It is concluded that the homogeneous tem perature required in combination with chemotherapy can be achieved by isola ted extremity perfusion, if a good thermal insulation is applied. If temper atures >42 degreesC are required, an additional external heat source (micro waves or ultrasound) is necessary. Although these sources may produce high absorption rates, combination with extremity perfusion is useful in reducin g higher temperature gradients and the danger of locally lower temperatures .