BAG-1 is a multifunctional chaperone modulator may contribute to p53-mediat
ed cell cycle arrest. We attempted to investigate whether BAG-1 expression
is correlated with prognosis of laryngeal carcinoma patients after radiothe
rapy. Immunohistochemical analyses revealed BAG-1 expression was present in
all laryngeal carcinomas examined, and its expression pattern varied, i.e.
cytoplasmic, nuclear and both these staining types. Patients whose tumors
predominantly express nuclear BAG-1 have a significantly poor failure-free
survival rate after radiotherapy. We thus propose that nuclear BAG-1 locali
zation is a prediction of unfavorable outcome should radiation therapy be u
ndertaken for laryngeal carcinoma patients. (C) 2001 Elsevier Science Irela
nd Ltd. All rights reserved.